_1603473375 1603473375 Hamid Shirkhanloo sahar.zi67@gmail.com Hamid Shirkhanloo Analytical Methods in Environmental Chemistry Journal AMECJournal 2645-5382 2645-5552 09 30 2020 3 03 10.24200/amecj.v3.i03 http://journal.amecj.com/index.php/AMECJ-01/issue/view/15 Mohammad Reza Rezaei Kahkha Gholamreza Ebrahimzadeh Ahmad Salarifar Antibiotics and pharmaceutical products cannot remove by conventional sewage treatment. In this work, an effective adsorbent magnetic multiwalled carbon nanotube (Fe3O4@MWCNTs) was synthesized by co-precipitation of MWCNTs with Fe3O4 and used for removal of Metronidazole from aqueous solutions. Response surface methodology on central composition design (CCD) was applied for designing of experiments and building of models for Metronidazole removal before a determination by HPLC. Four factors including pH, the adsorbent dose, time, and temperature were studied and used for the quadratic equation model to the prediction of optimal points.  By solvent the equation and considering the regression coefficient (R2 =0.9997), the optimal points obtained as follows: pH =2.98; adsorbent dosage =2.16 g; time =22 min and temperature = 37.9 o C. The isotherm study of adsorption showed that the metronidazole adsorption on Fe3O4@MWCNTs follows the Langmuir model. The maximum adsorption capacity (AC) is 215 mg g-1 obtained from Langmuir isotherm. 09 29 2020 44 53 http://creativecommons.org/licenses/by/4.0 10.24200/amecj.v3.i03.110 http://journal.amecj.com/index.php/AMECJ-01/article/view/110 http://journal.amecj.com/index.php/AMECJ-01/article/download/110/222 http://journal.amecj.com/index.php/AMECJ-01/article/download/110/222 http://journal.amecj.com/index.php/AMECJ-01/article/download/110/223